Case series: 8 patients exposed to phony alprazolam (Xanax) containing fentanyl and/or etizolam

August 24, 2016, 11:50 pm

★★★☆☆

Adverse Effects From Counterfeit Alprazolam Tablets. Arens AM et al. Ann Emerg Med 2016 Aug 8 [Epub ahead of print]

Reference

In March of this year,there were 9 deaths reported in Pinellas County, Florida (the Tampa/St. Petersburg area) associated with fake alprazolam (Xanax) tablets containing fentanyl. Earlier, similar counterfeit pills had been seen around San Francisco and in Monroe County …

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State-of-the-art review of lithium poisoning: almost a must-read

August 19, 2016, 9:50 pm

Lithium★★★★☆

Lithium Poisoning: State of the Art.  Baird-Gunning J et al. J Intensive Care Med 2016 Aug 11 [Epub ahead of print]

Abstract

This is a very good paper, the best comprehensive review I can remember reading on lithium. It is up to date, with 78 references as recent as 2015. A major reason I liked it so much is that …

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Elephant-tranquilizer (carfentanil)-tainted heroin showing up in Ohio

August 10, 2016, 2:55 pm

★★★★☆

Human Health Hazards of Veterinary Medications: Information for Emergency Departments. Lust EB et al. J Emerg Med 2011 Feb;40:198-207

Abstract

Yesterday, Canadian police announced that, earlier in the summer, they had seized one kilogram of carfentanil contained in a package labelled “Printer Parts” shipped from China and addressed to a man in Calgary.

Carfentanil is frequently, and accurately, referred to …

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Seven cases of laboratory-confirmed exposures to the synthetic cannabinoid MDMB-CHMICA

August 8, 2016, 6:53 pm

sweetleafherbalbend3.5g-1-300x300★★★☆☆

Clinical toxicity following analytically confirmed use of the synthetic cannabinoid receptor agonist MDMB-CHMICA. A report from the Identification Of Novel psychoActive substances (IONA) study. Hill SL et al. Clin Toxicol 2016 Sep;54:638-643.

Abstract

MDMB-CHMICA is a synthetic cannabinoid receptor agonist (SCRA) with strong affinity for the CB1 receptor. It has to date not been banned in may localities, …

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Counterfeit Norco containing fentanyl and the synthetic opioid U-47700

July 28, 2016, 6:30 pm

★★★☆☆

Fentanyl and a Novel Synthetic Opioid U-47700 Masquerading as Street “Norco” in Central California: A Case Report. Armenian P et al. Ann Emerg Med 2016 [Epub ahead of print]

Full Text

In a recent “Toxicology Rounds” column for Emergency Medicine News, I pointed out that designer opioids such as U-47700 are being identified in street drug specimens and overdose …

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All bleeding stops — but does idarucizumab (Praxbind) make it stop faster?

July 27, 2016, 2:56 pm

PraxBind★★★½☆

Persistent life-threatening hemorrhage after administration of idarucizumab. Alhashem HM et al. Am J Emerg Med 2016 June 30 [Epub ahead of print]

Reference

Dabigatran (Pradaxa) is a direct thrombin inhibitor approved for stroke and embolism prophylaxis in patients with non-valve-related atrial fibrillation. When it was first released in 2008, a major disincentive to widespread use was the lack of a …

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A normal (or negative) anion gap does NOT rule out salicylate toxicity

July 23, 2016, 4:40 pm

Aspirin_Tabs-300x236★★★☆☆

Salicylate toxicity in the absence of anion gap metabolic acidosis. Bauer S, Darracq MA. Am J Emerg Med  2016 Jul;34(7):1328.e1-3

Reference

Moderate-to-severe salicylate toxicity typically presents with a combined metabolic acidosis and respiratory alkalosis. Often, the arterial blood gas shows a pH quite near the normal 7.4, but with decreased pCO2 and decreased bicarbonate.

However, occasional case reports have …

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Fentanyl can cause serotonin syndrome

July 7, 2016, 10:21 pm

  • Fentanyl★★★½☆

Serotonin Syndrome Induced by Fentanyl in a Child: Case Report. Robles LA. Clin Neuropharmacol 2015 Sept-Oct;38:206-8.

Abstract

When many clinicians think of serotonin syndrome (SS), they consider the usual suspects:

Aside from these common culprits, there are other commonly used drugs …

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Loperamide (Imodium) overdose can cause fatal cardiac toxicity

July 3, 2016, 10:30 pm

Loperamide

A recent paper described two fatalities associated with overdose of the anti-diarrhea drug loperamide (Imodium.) This drug, once available by prescription only, had been thought so safe that in 1988 it was approved for purchase over-the-counter. Here are some important questions regarding this medication:

  • Why is it sometimes called the “poor man’s methadone”?
  • Why, despite having typical opiate μ-receptor activity,

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