Great New Toxicology Podcast

June 16, 2017, 12:36 am

In the first episode of “The Dantastic Mr. Tox & Howard Show,” Drs. Dan Rusyniak and Howard Greller — formerly of the Journal of Medical Toxicology Podcast — have a superb discussion about the current expanding opioid crisis with Dr. David Juurlink from Sunnybrook Health Sciences Centre in Toronto. Topics covered include opioid-induced hyperalgesia, the key difference between relieving …

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Episode #15: How easy is it to get addicted to opioids?

June 10, 2017, 11:17 pm

A recent article in the New York Times reported that there were likely more than 59,000 deaths from opioid overdose in the United States during the year 2016, an increase of 19% over the number of such deaths in 2015. Many of these victims became addicted to narcotics after being prescribed opioid analgesics for episodes of acute pain. Previously, physicians were told that the incidence of addiction in this setting were virtually zero. It is now known that this is not true. But just how easy is it go get addicted to opioid medication used to treat pain? In this episode, Steve Aks and I will discuss.
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Lipid rescue therapy for local anesthetic toxicity: is less more

May 25, 2017, 5:09 pm

★★½☆☆

Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity. Corwin DJ et al. Clin Toxicol 2017 Jul;55:603-7.

Abstract

The key word in the title of this case report is “associated” — a.though the authors do not emphasize the point, it’s not at all clear that all of the adverse events described were actually …

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Hemodialysis and the intubated salicylate-toxic patient

May 20, 2017, 12:53 pm

★★★½☆

The association of hemodialysis and survival in intubated salicylate-poisoned patients. McCabe DJ, Lu JJ. Am J Emerg Med 2017 Apr 10 [Epub ahead of print]

Abstract

[Disclosure: the co-authors of this paper are members of the Toxikon Consortium in Chicago, as am I.]

This retrospective observational study looked at cases from the Illinois Poison Center over 12 years (2003 thru 2015) …

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Hemp seed oil may possibly (but not probably) cause cannabinoid poisoning

May 10, 2017, 1:41 am

hemp seed oil★★½☆☆

Cannabinoid Poisoning by Hemp Seed Oil in a Child. Chinello M et al. Pediatr Emerg Care 2017;33:344-345.

Abstract

This interesting but non-dispositive short case report from Italy suggests that, in rare instances, commercially marketed hemp seed oil can cause mild cannabinoid toxicity. A 2-year-7-month old male was brought to hospital with altered mental status and several hours of “decreased alertness, …

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Tox Tunes #110: Nutmeg (John Legend & Stephen Colbert)

May 7, 2017, 1:38 pm

Started thinking about this song again earlier in the week as I prepared to take part in an hour-long discussion of the spice on Connecticut Public Radio’s Colin McEnroe Show. The discussion touched on many aspects the spice: historical, economic, culinary, medicinal, and toxicological.

To listen to the show, click here.

To read my 2011 Emergency Medicine News

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TPR Podcast Episode #14: VX and the Assassination of Kim Jong-Nam

March 30, 2017, 2:43 pm

When Kim Jong Nam — the half-brother of Korean leader Kim Jong Un — was assassinated in February while waiting for a flight at the Kuala Lumpur International Airport in Malaysia, attention was focused on one of the deadliest chemicals in the world: the nerge agent VX. What is VX, why is it such an effective poison, and how are victims of exposure managed medically. These are some of the questions we'll be examining in this edition of the TPR podcast.
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Tox Tunes #109: I Killed Robert Johnson (The Stone Foxes)

March 5, 2017, 10:20 pm

More myths and legends are attached to the life of Robert Johnson (1911 – 1938) than surround any other American blues artist. It’s said that he sold his soul to the devil down at a Mississippi crossroads in return for the ability to play guitar with a technique that musicians like Eric Clapton are still trying to replicate. It’s said …

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Labetalol in acute cocaine toxicity: is it safe?

March 1, 2017, 2:10 pm

Cocaine-medical-grade★★★☆☆

Acute Toxicity from Topical Cocaine for Epistaxis: Treatment with Labetalol. Richards JR et al. J Emerg Med 2017 Mar;52:311-313.

Abstract

There has long been a debate among toxicologists — still unresolved — as to whether it is safe to use a beta-blocker to treat cocaine-related hypertension and tachycardia. The (theoretical) concern is that since cocaine is both an α- and …

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