DIMERCAPTOSUCCINIC ACID (SUCCIMER; DMSA) IN INORGANIC LEAD POISONGING Bradberry S, Vale A. Clin Toxicol 47:617-631.
This is an ambitious paper and I really hoped to find it more helpful than I actually did. The authors performed a literature review, considering a whopping 912 papers (and reviewing in detail 50 papers) concerning the treatment of inorganic led poisoning with succimer. …
DEA Recruits Lil Wayne To Use Up All Drugs In Mexico
From the Onion News Network. Thanks to DoseNation for the link.
EXPERT CONSENSUS GUIDELINES FOR STOCKING OF ANTIDOTES IN HOSPITALS THAT PROVIDE EMERGENCY CARE Dart RC et al. Ann Emerg Med 2009;54:386.
This article is essential reading for all physicians and clinical pharmacists who participate in or plan for the care of poisoned patients. Inadequate stocking of crucial antidotes in hospitals and emergency has been a persistent and well-documented problem. …
PRESCRIBING OF OPIOID ANALGESICS AND RELATED MORTALITY BEFORE AND AFTER THE INTRODUCTION OF LONG-ACTING OXYCODONE Dhalla IA et al. Canad Med Assoc J Dec 8 2009;181:891-896.
The authors surveyed trends in the number of prescriptions written for opiate analgesics in the province of Ontario for the years 1991 to 2007, as well as deaths attributed to opiate overdose from …
A recent post by Richard Metzger on Brand X site questions whether the widely reported samples of ecstasy tablets shaped like President Obama’s head actually contained the drug (MDMA). He mentioned a recent seizure of this product in North Carolina that — upon analysis by GC/MS — was shown to cotain BZP (benzylpiperazine), TFMPP (trifluoromethylphenylpiperazine) and caffeine.
However, his reporting …
CARBAMATE POISONING: TREATMENT RECOMMENDATIONS IN THE SETTING OF A MASS CASUALTIES EVENT Rosman Y et al. Am J Emerg Med 2009;27:1117-1124.
This paper, from the Israel Poison Information Center in Haifa, discusses the controversial issue of the role of oximes (such as 2-PAM) in treating carbamate toxicity. Unlike organophosphates, carbamates cause reversibleinhibition of anticholinesterase. Therefore, it would make …
Mithridates VI of Pontus (134 – 63 B.C.) was one of the most significant figures in the early history of toxicology. An implacable enemy of Rome, Mithridates lived in constant fear of being poisoned, and sought to develop a universal antidote. According to legend he ingested increasing doses of toxins in order to develop tolerance. History reports that this practice …
AN ATROPINE AND GLYCOPYROLATE COMBINATION REDUCES MORTALITY IN ORGANOPHOSPHATE POISONING Arendse R et al. Hum Exp Toxicol 2009;28:715-720.
This retrospective review from South Africa studied the records of 53 patients admitted to their hospital with organophosphate ingestion over a 4-year period (2003-2006), comparing them with a loosely-defined control group of similar patients admitted during the years 1979-1985. Their hypothesis was based …
SEVERE VALPROIC ACID INTOXICATION: CASE STUDY ON THE UNBOUND FRACTION AND THE APPLICABILITY OF EXTRACORPOREAL ELIMINATION van den Broek MPH et al. European J Emerg Med 2009;:330-332.
This case report makes the point that although valproic acid (VPA) is largely bound to protein at therapeutic concentrations, in overdose the protein-binding sites become saturated and a greater percentage of the drug is …
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