Archive for May 2010

Naphyrone (nrg-1) being sold over internet as “pond cleaner”

May 30, 2010, 2:03 pm

In the wake of the recent reclassification of mephedrone (4-methylmethcathinone) in Britain as a class B drug, new chemicals — many apparently manufactured in China — have rushed to fill the void.  According to press reports, the most prevalent of these is naphyrone (nrg-1), which is sold over the internet where it is often labelled as a “…

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Tox Tunes #20: Cocaine Habit Blues (Memphis Jug Band)

May 30, 2010, 1:01 pm

The Memphis Jug Band recorded in the 1920s and 30s with an ever-changing line-up of musicians and instruments, usually including a liquor jug used as a wind instrument to supply the bass line.  According to the Black Media Archive, the personnel on this track included Will Shade (harmonica), Tee Wee Blackman (guitar), Ben Ramey (kazoo), Ham Lewis (jug), and …

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Mephedrone not responsible for two deaths in Britain

May 29, 2010, 11:29 am

In April,the Labour government banned mephedrone (4-methylmethcathinone) in part because the deaths of two British teenagers were associated with the drug. Yesterday, The Guardian (U.K.) reported on the results of post-mortem toxicology tests: no mephedrone was found in the teens' bodies. The paper interviewed Professor Roumen Sedefov from the European Monitoring Centre for Drugs and Drug Addiction, who stated he was aware of only one death clearly linked to mephedrone -- that of a woman in Sweden. It is not clear from the story whether methadone was also involved in that death. The New Scientist also reports on this story, and provides a link to a compilation of mephedrone myths, including one headlined "Legal drug teen ripped his scrotum off".

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Botticelli’s “Venus and Mars” and Jimson Weed

May 27, 2010, 1:50 pm

An article today in The Telegraph (U.K.) claims that Botticelli’s great painting “Venus and Mars” depicts not post coital bliss (or tristesse) but Jimson Weed (Datura stromonium) poisoning!  A description from London’s National Gallery, which displays the painting, comments that: “The scene is of an adulterous liaison, as Venus was the wife of Vulcan, the …

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Mephedrone

May 27, 2010, 1:02 am

Life in the Fast Lane has a nice review of mephedrone (meow-meow) toxicity.…

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Paraquat Ingestion: Case Report

May 26, 2010, 10:13 pm

★★★★☆

Paraquat Ingestion: A Challenging Diagnosis.  Chen JG et al. Pediatrics June 2010;125(6):e1506-e1509

Abstract

This very interesting case report from Duke and East Carolina University describes a 8-year-old boy who was brought to the emergency department several hours after ingesting a liquid herbicide that his parents identified as Amoxone (2,4-D) — a relatively non-toxic compound whose clinical effects are generally limited …

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Isoniazid, seizures, and pyridoxine

May 26, 2010, 1:48 am

★★★☆☆

Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy.  Minns AB et al.  Pediatr Emerg Care 2010;26:380-381.

Abstract

This short case report describes at 0-month-old male infant who ingested up to 2.7 gm of isoniazid (INH).  He had a seizure approximately 45 minutes after ingestion and was treated with pyridoxine (70 mg/kg) and diazepam (1 mg).  Because of …

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Tox Tunes #19: Torn and Frayed (The Rolling Stones)

May 24, 2010, 1:21 am

I’ve ordered a copy of the new remastering of The Rolling Stones’ “Exile on Main Street” and am looking forward to hearing it — especially the previously unreleased material. Although some critics think that “Exile” is The Stones’ masterpiece, I do have to admit that I agree with the opinion expressed this morning by Ben Ratliff in The New York

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Venlafaxine overdose and Tako Tsubo (broken heart) syndrome

May 23, 2010, 12:50 pm

httpv://www.youtube.com/watch?v=CMUJOYyJqwc&feature=related [Rating: 3.5] Broken heart syndrome: Tako Tsubo cardiomyopathy associated with an overdose of the serotonin-norepinephrine reuptake inhibitor Venlafaxine. Christoph M et al. Eur Neuropsychopharmacol 2010 (Epub ahead of print) Abstract Tako Tsubo cardiomyopathy (broken heart syndrome) is a unique clinical entity in which excess catecholamines -- often associated with physical or emotion stress -- cause acute left ventricular (LV) apical dysfunction. This can present similarly to acute coronary syndrome, with chest pain, dyspnea, ST elevation and/or T-wave inversion, and minimally elevated cardiac enzymes. Echocardiogram shows . . .

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