Naphyrone (nrg-1) banned in Britain

July 13, 2010, 12:01 pm

The government in the U.K. has initiated steps to make the street drug naphyrone (nrg-1) a class B substance. As The Independent reports, this follows a recommendation last week by the Advisory Council on the Misuse of Drugs (ACMD) to ban the substance.

Naphyrone — a triple reuptake inhibitor — increases levels of free norepinephrine, dopamine, and serotonin.  There are no studies in the scientific literature concerning the toxicity of this drug, a point made by former ACMD chairman David Nutt in arguing that banning naphyrone makes little sense.

Naphyrone was one of the drugs that became more prevalent in Britain after mephedrone (meow-meow) was made Class B. However, tests showed that much of what was sold labelled as “naphyrone” actually contained mephedrone and other similar drugs.


  1. Neuroskeptic Says:

    I recently blogged about tesofensine, another triple reuptake inhibitor. It’s being developed for obesity, it seems to work, and it has little to no abuse potential because of its extremely slow oral absorption. However, if it ever does make it to the market, I’m sure recreational users will find a way to get it into them quicker. halflife: ~220 h (sic).

  2. Leon Says:

    Neuroskeptic: I found your post very interesting, and LOVED the Mickey Mouse cartoon. Tesofensine sounds like an interesting drug, but I’d be frightened of any medication with a half-life that long taken daily. One of the adverse effects reported in the trials was insomnia, and it seems possible that one could end up going without sleep for weeks. (Might finally make it through all my recorded episodes of “Mad Men”, though.) I’d rather take my chances on being a few pounds on the wrong side of Alberto Contador.