Archive for November 2010

“Ivory Wave” Bath Salts purchased in St. Louis area contain pyrovalerone

November 30, 2010, 6:29 pm

KTVI-Fox2 news in St. Louis ran a piece yesterday about “Ivory Wave Bath Salts”, a product that has been available in Britain and found to contain the stimulant MDPV. Recently it has begun to appear in the United States. Tests done by the St. Louis County Medical Examiners Office revealed that the local product contained pyrovalerone and, apparently, lidocaine.…

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Fatal Sparkle Lamp Ingestion: Case Report

November 30, 2010, 11:44 am

★★★½☆

Sparkle lamp ingestion: a rare cause of death. Grundlingh J et al. Clin Toxicol 2010;48:854-856.

Abstract

“Sparkle lamps” are electronic decorative products containing fluid and reflective particles.  The lamp base emits light and heats the fluid so that the particles move by convection. Although the contents of these lamps are generally non-toxic, there are no manufacturing standards and quality varies.…

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Pediatric doses of acetaminophen safe

November 29, 2010, 12:04 pm

★★★★☆

Therapeutic Acetaminophen Is Not Associated With Liver Injury in Children: A Systematic Review.  Lavonas EJ et al. Pediatrics 2010 Nov 22. [EPub ahead of print]

Abstract

For reasons that are hard to fathom, some authors have suggested that even when administered at recommended therapeutic doses ( < 75 mg/kg per day PO), acetaminophen (APAP) can cause clinically significant hepatic injury …

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It ain’t tox, but . . .

November 28, 2010, 7:39 pm

Bob Wachter’s post about a recent case discussion in the New England Journal of Medicine is quite interesting.  As Wachter points out, the NEJM piece is historic because it represents the first time that the Journal‘slong-running feature “Case Records of the Massachusetts General Hospital” focused on medical errors rather than on genius diagnoses and obscure medical disorders.

The case …

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Toxicology Journal Club Podcast

November 26, 2010, 11:34 am

The Medical Toxicology Program at Oregon Health & Science University has a website featuring podcasts of their Journal Club sessions. Recent topics have included methylene blue, botulism, and fospropofol.  The discussions are comprehensive, detailed, and informed, and worth adding to one’s mobile CME schedule for listening to in a car or on a plane.  It is also possible to subscribe …

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Methylene Blue and Serotonin Syndrome

November 24, 2010, 12:49 pm

★★★½☆

Serotonin syndrome following Methylene Blue infusion: a rare complication of antidepressant therapy. Heritier Barras AC et al. J Neurol Neurosurg Psychiatry Dec 2010;81:1412-3.

No abstract available

Toxicologists know methylene blue (MB) as the antidote for methemoglobinemia.  The dye is also used by surgeons to help locate the parathyroid gland during parathyroidectomy.  This brief case report describes a 77-year-old woman who

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A bad case of the blues

November 24, 2010, 12:07 am

★★★☆☆

Getting the blues at a rock concert: A case of severe methaemoglobinaemia. Wilkerson RG. Emer Med Australasia 2010;22:466-469.

Abstract

A 19-year-old woman ingested a bottle of ‘Liquid Gold’ (amyl nitrite) that her friends had been sniffing at an outdoor music festival in Tasmania.  She was taken to hospital after she passed out, where a grey-blue skin color was noted and …

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Thiazides and Hypercalcemia

November 22, 2010, 2:24 pm

★★★☆☆

Thiazide-Induced Severe Hypercalcemia: A Case Report and Review of Literature. Desai HV et al. Am J Ther 2010 Nov-Dec;17:e234-6.

Abstract

This interesting case report describes a 59-year-old woman who presented to the emergency department with a 3 day history of progressive nausea, vomiting, constipation, abdominal pain, and lethargy. Work-up revealed that her serum calcium was 19.8 mg/dL and ionized calcium …

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Tox Tunes #34: A Girl Named Sandoz (Smashing Pumpkins)

November 21, 2010, 2:55 pm

This is the Smashing Pumpkins‘ cover of “A Girl Named Sandoz”, which came out in 1967 as the B-side of “When I Was Young” by Eric Burdon and the Animals.  “Sandoz” of course refers to the pharmaceutical company in Basel, Switzerland where Albert Hofmann was employed when in 1938 he synthesized LSD-25 and, five years later, discovered its …

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