Archive for April 2013

Case report: toxicity from designer drug 25I

April 29, 2013, 9:55 pm

25I-NBOMe

25I-NBOMe

★★★½☆

A case of 25I-NBOMe (25I) intoxication: a new potent 5-HT2A agonist designer drug. Rose SR et al. Clin Toxicol 2013;51:174-177.

Abstract

The designer drug 25I-NBOMe is an extremely potent serotonin agonist. Since it is so new, there have been few case reports of toxicity reported in the medical literature. However, there have been several fatalities associated with use of …

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Weekly Web Review: ricin, gila monsters, and Hitler’s food taster

April 27, 2013, 5:19 pm

Caster beans and ricin: At the ToxTalk podcast, Matt Zuckerman, Jen Carey, and Ed Boyer from the University of Massachusetts toxicology program have a level-headed discussion as to whether or not one should panic if an envelope filled with ricin arrives in the mail. I was especially interested to hear about their recent case of a suicidal man who …

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Case report: hemodialysis for dabigatran overdose

April 23, 2013, 7:22 pm

Pradaxa★★★☆☆

Hemodialysis for the Treatment of Pulmonary Hemorrhage from Dabigatran Overdose. Chen BC et al. Am J Kidney Dis 2013 Apr 15 [Epub ahead of print]

Abstract

Dabigatran (Pradaxa) is a competitive direct thrombin inhibitor approved in the United States for stroke prophylaxis in patients with nonvalvular atrial fibrillation. Although dabigatran has certain advantages over coumadin related to issues of dosing …

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The Cinnamon Challenge

April 22, 2013, 7:04 pm

★★★½☆

Ingesting and Aspirating Dry Cinnamon by Children and Adolescents: The “Cinnamon Challenge” Grant-Alfieri A et al. Pediatrics 2013 Apr 22 [Epub ahead of print]

Full text

There are thousands of videos on YouTube of individuals attempting the “Cinnamon Challenge“, which involves ingesting one tablespoon of ground cinnamon without the aid of water or fluids to wash it down. …

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Tox Tunes # 72: Acid Polka (Bob Franke)

April 21, 2013, 2:06 pm

Thanks to Rich Warren and The Midnight Special on WFMT in Chicago for playing this song last week. I had not heard it before.…

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Does early GI decontamination improve outcomes in acute-on-chronic lithium toxicity

April 19, 2013, 5:55 pm

eskalith★★½☆☆

Lithium poisoning: the value of early digestive tract decontamination. Bretaudeau Deguigne MB et al. Clin Toxicol 2013 May;51:243-248.

Abstract

Although whole bowel irrigation is being used less and less as a means of gastrointestinal decontamination in cases of overdose, one possible remaining indication is a potentially significant ingestion of a poison that is not well absorbed to activated charcoal. Practically, …

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Ricin danger mostly theoretical

April 17, 2013, 9:26 pm

Castor beans

Castor beans

A Mississippi man was arrested today under suspicion of sending letters to President Obama and Senator Roger Wicker (R-Miss) that gave a positive preliminary test for ricin. Further, more conclusive tests are under way.

In the wake of the bombings at the Boston Marathon, it is understandable that this revelation would be unsettling, inevitably brining to mind …

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Weekly Web Review in Toxicology #3

April 14, 2013, 12:20 pm

Was Pablo Neruda poisoned: The journal Nature posted an article asking whether, at this late date, science is capable of determining whether the Nobel-prize-winning Chilean poet Pablo Neruda was poisoned.

Neruda’s death in 1973 occurred less than 2 weeks after a coup d’etat in Chile deposed Socialist President Salvador Allende and installed a right-wing dictatorship led by Augusto Pinohcet. The …

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Cases of methanol poisoning among tourists in Indonesia

April 10, 2013, 11:56 pm

arak★★★☆☆

Methanol poisoning among travellers to Indonesia. Giovanetti F. Travel Med Infect Dis 2013 Apr 6 [Epub ahead of print]

Abstract

In 2009, 25 people died in Indonesia after consuming samples of the popular local drink called arak (or arrack) that had been contaminated with methanol. Since then, reports of fatal cases of methanol poisoning related to the drink have …

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