The top 5 things to know about tramadol

April 4, 2013, 11:54 pm


Tramadol. Young JWS, Juurlink DN. CMAJ 2013 Mar 18 [Epub ahead of print]

No abstract available

This quick one-page review covers some basic clinical and pharmacological points about tramadol. These include:

  • The major analgesic effect of tramadol comes from its metabolite — O-desmethyltramadol (M1) — whic is an opioid.
  • Tramadol’s metabolism can vary considerably, with some individuals being “poor metabolizers” and other “ultra-rapid metabolizers”.
  • Tramadol’s analgesic effectiveness is only modest.
  • Ultra-rapid metabolizers are especially susceptible to opioid dependence and toxicity from tramadol
  • Tramadol can cause seizures, especially when combined with other proconvulsant drugs.

Related posts:

Does tramadol cause paradoxical hyperalgesia?

Tramadol and Brugada Syndrome


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