Archive for May 2015

Tox Tunes #95: Dead Flowers (Townes Van Zandt)

May 31, 2015, 11:09 pm

The Rolling Stones’ original version of “Dead Flowers” was on their 1971 Sticky Fingers album, along with a number of other songs definitely or possibly about drugs, including “Brown Sugar,” “Moonlight Mile,” and “Sister Morphine.”

The song was written in the late 1960s, when Keith Richards was hanging out with the country-rock musician Gram Parsons. Although fans …

Read More »

Poisoned patients treated with ECMO: 10 cases from the ToxIC Registry

May 30, 2015, 12:37 am

★★★☆☆

Extracorporeal Membrane Oxygenation (ECMO) for Severe Toxicological Exposures: Review of the Toxicology Investigators Consortium (ToxIC) Wang GS et al. J Med Toxicol 2015 May 27 [Epub ahead of print]

Abstract

The Toxicology Investigators Consortium (ToxIC) Case Registry — established in 2010 — is a database containing information from cases of known or suspected poisoning at multiple centers that were cared …

Read More »

Keys to the safe use of naloxone

May 28, 2015, 1:05 am

naloxone★★★★☆

Reducing the harm of opioid overdose with the safe use of naloxone: a pharmacologic review. Kim HK, Nelson LS. Expert Opin Drug Saf 2015 Apr 12:1-10 [Epub ahead of print]

Abstract

This review of naloxone comes down strongly on the side of “less is more,” and argues that when reversing opiate overdose a starting dose of 2 mg — or …

Read More »

Unlabeled amphetamine isomer in sports supplement “probably” caused hemorrhagic stroke

May 22, 2015, 12:06 am

Jacked_Power-300x300★★★½☆

Hemorrhagic Stroke Probably Caused by Exercise Combined With a Sports Supplement Containing β-Methylphenylethylamine (BMPEA): A Case Report. Cohen P et al. Ann Intern Med 2015 May 12 [Epub ahead of print]

Reference

Last month, the FDA sent letters to 5 companies that manufacture so-called “dietary” or “sports” supplements, warning them that their products were mislabeled because they contained an unlisted …

Read More »

ED sedation with droperidol is relatively safe and effective

May 19, 2015, 7:57 pm

droperidol★★★★☆

The Safety and Effectiveness of Droperidol for Sedation of Acute Behavioral Disturbance in the Emergency Department. Calver L et al. Ann Emerg Med 2015 Apr 11 [Epub ahead of print]

Abstract

Before the Food and Drug Administration issued a black box warning in 2001 regarding the relationship between droperidol and risk of QTc prolongation, the drug had been used for …

Read More »

Lipid rescue therapy and ECMO in the poisoned patient — can they be used together?

May 16, 2015, 5:12 pm

intralipid-161x300★★★☆☆

What are the adverse effects associated with the combined use of intravenous lipid emulsion and extracorporeal membrane oxygenation in the poisoned patient? Lee HM et al. Clin Toxicol 2015;53:145-150.

Abstract

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is often used in the neonatal and pediatric intensive care units on children who are also receiving intravenous lipid emulsion (LE) for nutritional support. Complications …

Read More »

Hemodialysis in metformin poisoning

May 8, 2015, 12:45 am

metformin3★★★½☆

Extracorporeal Treatment fo Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workshop. Calello DP et al. Crit Care Med 2015 Apr 9 [Epub ahead of print]

 

Abstract

Metformin is now the oral drug most commonly prescribed to treat non-insulin-dependent diabetes in the United States. The drug is large eliminated by the kidneys. Toxicity presents with …

Read More »