5F-ADB-PINACA and other extremely potent new synthetic cannabindoids

July 22, 2015, 5:18 pm

IndoleVSIndazole

★★★½☆

Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA. Banister SD et al. ACS Chem Neurosci 2015 July 17 [Epub ahead of print]

Abstract

As TPR noted in a recent post, many recently reported cases of severe toxicity or death associated with exposure to synthetic cannabinoids (SCs) involved relatively new and unfamiliar chemicals such as MAB-CHMINACA, AB-PINACA, and ADB-PINACA.

These new compounds incorporate either an indole or an indazole group, and have structured that can be altered seemingly ad infinitum by substituting various halide and organic groups at various sites in the molecules. They are all powerful agonists at CB1 receptors, with a least one agent being more than 1000 times more potent as a CB1 agonist than Δ9-THC itself.

Because not much is known or has been published about these agents, this paper is a welcome addition to the literature about SCs and novel designer drugs, although the material presented concerns issues of synthesis and structure more than clinical presentation and treatment.

I’d recommend this paper to chemical structure geeks, as well as clinicians who have recently seen reference to a number of new SCs with names ending in “ACA’ or “ICA” and want clarification as to exactly what these unfamiliar designer drugs are.

Related post:

Serious toxicity and fatalities from synthetic cannabinoids

 

 

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