Archive for December 2015

The 6th Annual Alexander Awards: The Best Tox Reading of 2015

December 31, 2015, 6:55 pm

Alexander Gettler

Alexander Gettler

At the end of every year, TPR bestows the coveted Alexander Awards on the best long-form writing on toxicology topics that have appeared in the popular press during the preceding 12 months. To be eligible, an article must be open-access and freely available, not locked behind some paywall. The awards were named for Alexander Gettler (1883-1968,) the head …

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Carbon monoxide “myths”

December 24, 2015, 4:47 pm

CO-KILLS-180★★½☆☆

Myth busting in carbon monoxide poisoning. Hampson NB. Am J Emerg Med 2015 Nov 3 [Epub ahead of print]

Abstract

This short review, by the former medical director for the Virginia Mason Center for Hyperbaric Medicine in Seattle, sets out to debunk four “myths” associated with carbon monoxide (CO) exposure. Although nothing here will surprise most emergency physicians, the paper …

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TPR Podcast Episode #10: Synthetic cannabinoids, “Crazy Monkey,” and a man and his dog

December 17, 2015, 1:17 am

In this episode of the Podcast, we discuss synthetic cannabinoids, the TuSH exam, and the tender story of a man and his dog. Enjoy!

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Tox Tunes # 103: I’ll Never Smoke Weed with Willie Again (Toby Keith & Scott Emerick)

December 13, 2015, 8:41 am

Yesterday we linked to a New York Magazine piece about Willie Nelson and his relationship with marijuana. As described in the article:

. . . Nelson’s tolerance is supernatural. He can easily smoke 30 or 40 hits in a session and then play a flawless two-hour show. He does not always deploy this talent toward noble ends. He is famous

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Tox on the Web: doomsday scams and more!

December 12, 2015, 4:31 pm

Apocalyptic Con Games: An article in The New York Times Magazine by C. J. Chivers sets out to find whether the purportedly extremely toxic and explosive compound “red mercury” actually exists. According to some reports, the Islamic State of Iraq and the Levant (ISIL or ISIS) has been trying to acquire samples in order to build a neutron bomb or …

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Case series: agitation and hallucinations after exposure to 25B-NBOMe (“N-bomb”)

December 8, 2015, 12:52 am

25B-NBOMe

25B-NBOMe

★★★½☆

Case series: toxicity from 25B-NBOMe — a cluster of N-bomb cases. Gee P et al. Clin Toxicol 2015 Dec 1 [Epub ahead of print]

Abstract

The NBOMe series of drugs are substituted phenethylamines. They act as agonists at both the 5-HT2A serotonin receptors and the α-receptors. Because of these actions they can cause both hallucinations (5-HT2A effects) …

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Effect of lipid rescue therapy on laboratory tests

December 3, 2015, 3:02 pm

intralipid-161x300★★★☆☆

Review of the effect of intravenous lipid emulsion on laboratory analyses. Grunbaum AM et al. Clin Toxicol 2015 Dec 1 [Epub ahead of print]

Abstract

Lipemic serum can interfere with laboratory measurements because of a number of factors: sample turbidity, partitioning, and cross-reactivity. Clinicians who are not aware of these effects can be misled by erroneous lab results in ways …

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Do labels accurately reflect THC content of medical marijuana edibles?

December 2, 2015, 10:34 pm

Atomazul/shutterstock.com

Atomazul/shutterstock.com

★★★½☆

Cannabinoid Dose and Label Accuracy in Edible Medical Cannabis Products. Vantrey R et al. JAMA 2015 Jun 23/30:2491-2493.

Reference

Titrating the dose of edible marijuana is difficult for a number of reasons, including differing rates of absorption and unpredictable metabolism involving active metabolites.

In addition, some states that have legalized medical marijuana have not instituted stringent monitoring and regulation …

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