Archive for June 2016

Acetaminophen and N-acetylcysteine are removed by hemodialysis

June 30, 2016, 1:39 pm


Massive acetaminophen overdose: effect of hemodialysis on acetaminophen and acetylcysteine kinetics. Ghannoum M et al. Clin Toxicol 2016 Jul;54:519-22.


As we’ve discussed before, massive acetaminophen [APAP] overdose may be a somewhat different beast from the usual, run-of-the-mill case that reliably responds to N-acetylcysteine [NAC] (if administered at an early stage.)There is evidence that a very large …

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A can’t miss item in the differential diagnosis of neuroleptic malignant syndrome

June 22, 2016, 5:25 pm


Psychiatric Emergencies for Clinicians: Emergency Department Management of Neuroleptic Malignant Syndrome. Wilson MP et al. J Emerg Med 2016;51:66-69.


This review article about neuroleptic malignant syndrome (NMS) is brief but disappointing and misleading on some points. For example, the authors state that:

The majority of cases of NMS develop symptoms within the first week [after starting the offending medication],

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