Archive for December 2017

Is there a better way to administer IV N-acetylcysteine?

December 14, 2017, 10:26 am

★★★☆☆

Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. McNulty R et al. Clin Toxicol 2017 Dec 8 [Epub ahead of print]

Abstract

Current recommendations for dosing intravenous N-acetylcysteine (Acetadote) for treating acute acetaminophen (paracetamol) poisoning involves a somewhat complex three-bag protocol, using 3 direct concentrations of the antidote given over a 21-hour period. Unfortunately, …

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Case series: treating cannabinoid hyperemesis syndrome with capsaicin cream

December 5, 2017, 5:27 pm

★★★☆☆

Resolution of cannabis hyperemesis syndrome with topical capsaicin in the emergency department: a case series. Dezieck L et al. Clin Toxicol 2017 Sep;55:908-913.

Abstract 

Cannabis hyperemesis syndrome (CHS) is a form of cyclic vomiting characterized by:

  • chronic marijuana use
  • recurrent vomiting, and
  • lack of alternate explanation for symptoms

A striking feature is that although CHS-induced nausea and vomiting are frequently …

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Tox Tunes #112: Chinese Rocks (Johnny Thunders & the Heartbreakers)

December 3, 2017, 11:34 pm

In a recent article discussing his favorite songs, food/travel guru Anthony Bourdain comments: “My early honeymoon period with heroin; this song made an other ill considered lifestyle option seem like a good idea.”

Bourdain probably wasn’t paying close attention to the lyrics, which describe something other than a wise personal choice:

I’m living on a Chinese Rock
All my best

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