Comprehensive up-to-date review of toxic alcohol poisoning

January 30, 2018, 1:05 am


Toxic Alcohols. Kraut JA, Mullins ME. N Engl J Med 2018 Jan 18;378:270-280.


This is a good general review and update of clinical issues regarding the major toxic alcohols: methanol, ethylene glycol, isopropanol, diethylene glycol, and propylene glycol.

The article is chockablock with information, and would I think be somewhat difficult to follow if one was not already familiar with these agents. For those wishing to learn the subject de novo, a good introductory book chapter in a toxicology or emergency medicine text would be better. But this is a very good refresher for those already comfortable with osmolal and anion gaps, alcohol dehydrogenase inhibitors, and indications for hemodialysis in these poisonings.

80 up-to-date references.

Related posts:

Hemodialysis in acute methanol poisoning: is there really good evidence?

NEJM discussion of ethylene glycol poisoning misses important points

Can hemodialysis be avoided in selected patients with significant serum levels of ethylene glycol?

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Do all patients with significantly elevated ethylene glycol levels need to be dialyzed?

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Severe ethylene glycol toxicity — did therapeutic* vodka really contribute to a good outcome?


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