Archive for the ‘Medical’ Category

Case report: Amanita muscaria (fly agaric) poisoning

February 8, 2016, 11:05 pm

Mikhail Kochlev/shutterstock.com

Mikhail Kochlev/shutterstock.com

★★☆☆☆

Coma in the course of severe poisoning after  consumption of red fly agaric (Amanita muscaria). Mikaszewska-Sokolewicz MA et al. Acta Biochim Pol 2016 Feb 1 [Epub ahead of print]

Full Text

Probably the most recognizable mushroom in the world is Amanita muscaria (the “fly agaric”), This striking red-and-white fungus contains several distinct neurotoxins:

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W-18, a synthetic opiate 100 times more potent than fentanyl

February 4, 2016, 2:01 pm

W-18

W-18

Last August, Canadian police seized 110 illegal fentanyl pills at a home in Alberta province. Yesterday, Global News reported that some of the pills have tested positive for an extremely potent opioid called W-18.

This is certainly a disturbing development, since W-18 is a μ-receptor agonist 100 times more potent than fentanyl. According to B.C. Centre for Disease

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Coronary artery vasospasm induced by cocaine (maybe)

February 4, 2016, 12:52 am

★★½☆☆

Cocaine-Induced Coronary Artery Vasospasm. Almaddah N, Ajayi TO. N Engl J Med 2016 Feb 4;374:e5

Full Text with video

In a series of amazing studies that are now about three decades old, Richard Lange and his colleagues at Parkland Hospital in Dallas investigated the cardiovascular effects of administering intranasal cocaine to patients to patients during cardiac catheterization for routine workup …

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Tox Tunes #105: How Can a Poor Man Stand Such Times and Live (Ry Cooder)

January 31, 2016, 9:52 pm

Well the doctor comes around with a face all bright,
And he says in a little while you’ll be all right.
All he gives is a humbug pill,
A dose of dope and a great big bill —
Tell me how can a poor man stand such times and live?

“How Can a Poor Man Stand Such Times and Live” …

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Saturday with SMACC: Strayer on how to use opioids (and how not to use opioids)

January 30, 2016, 11:12 pm

smacc-dublin

The 3rd (and final) release of registrations for the 2016 Social Media and Critical Care (SMACC) conference in Dublin (June 13-16) will take place on February 3 at 09:00 Sydney time — or 4 pm Tuesday February 2 Chicago time. The 2nd release early December sold out in just one hour (!) after being posted,  so if you’re interested in …

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Cannabis psychopharmacology: it’s more complex than you might imagine

January 29, 2016, 6:06 pm

Yarygin/shutterstock.com

Yarygin/shutterstock.com

★★★½☆

The Cannabis sativa Versus Cannabis indica Debate: An Interview with Ethan Russo, MD. Cannabis and Cannabinoid Research 2016 Jan;1:44-46

Full Text

This short interview with Ethan Russo MD should be of interested to toxicologists and other clinicians who might counsel patients on issues regarding medical marijuana. It contains some interesting information about the different biologically active chemicals contained in …

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Extracorporeal treatment for digoxin toxicity: just say no

January 28, 2016, 3:42 pm

digoxin5★★★☆☆

Extracorporeal treatment for digoxin poisoning: systematic review and recommendations from the EXTRIP Workgroup. Mowry JB et al. Clin Toxicol 2016 Feb;54:103-14.

Abstract

“Forced diuresis, and hemodialysis are ineffective in enhancing the elimination of digoxin because of its large volume of distribution (4-10 L/kg), which makes it relatively inaccessible to these techniques.” Goldfrank’s Toxicologic Emergencies (Tenth Edition, 2015)

That one sentence …

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Tox on the Web: deadly French drug trial, fatal food, and more!

January 23, 2016, 6:42 pm

 

 

Must-read post about the catastrophic phase 1 French drug trial: In a superb must-read post at the Forbes magazine website,  David Kroll discusses what we know about the disastrous drug safety trial in France that left 1 subject dead and 4 others with varying degrees of neurological damage.The drug in question — named BIA 10-2474 — is an …

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Happy Birthday, Wilbur Scoville! (1865-1942)

January 22, 2016, 12:46 am

Pass the Carolina Reaper!…

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