Critical Care Management of Verapamil and Diltiazem Overdose with a Focus on Vasopressors: A 25-Year Experience at a Single Center. Levine M et al. Ann Emerg Med 2013 May 1 {Epub ahead of print]
This uncommonly interesting and thought-provoking study comes from the Department of Medical Toxicology at Banner Good Samaritan Medical Center in Phoenix. The authors note that …
Sous Influences. DOCU. by lamaisonrouge
Just returned from a short stay in Paris, where I saw the art exhibit Sous Influences (Under Influences: Artists and Psychotropics) at the Maison Rouge. Although somewhat disjointed and often lacking sufficient context, the show had a number of fascinating works, including Bryan Lewis Saunders‘ series of self-portraits done under the influence of …
Metformin overdose-induced hypoglycemia in the absence of other antidiabetic drugs. Al-Abri SA et al. Clin Toxicol 2013 Apr 1 [Epub ahead of print]
Hypoglycemia association with metformin overdose has been reported but is distinctly unusual. In cases published previously, it has not been clear if factors other than metformin toxicity — such as co-ingestion of other hypoglycemic agents or …
Police are suspecting that the death of a prominent Pittsburgh neurologist was related to cyanide poisoning. Dr. Autumn Klein collapsed at her home in late April and died 3 days later. Although initial tests detected cyanide, both false positive and false negative results are possible. Final test results may not be available for weeks.
A post on the Scientific …
Sodium Acetate as a Replacement for Sodium Bicarbonate in Medical Toxicology: a Review. Neavyn MJ et al. J Med Toxicol 2013 Apr 30 [Epub ahead of print]
Sodium bicarbonate is used frequently to treat specific overdoses, including those from salicylates, as well as tricyclic antidepressants and other sodium channel blockers that increase the QRS interval. Goals of therapy with …
Exposures to Discarded Sulfur Mustard Munitions — Mid-Atlantic and New England States 2004-2012. MMWR 2013 Apr 26;62:315-316.
Prior to 1970, the U.S. military commonly dumped chemical munitions at sea. Among these munitions are those containing sulfur mustard, a vesicant or blistering agent. Manifestations of sulfur mustard exposure include burning, irritation or blistering of the skin …
25I-NBOMe
A case of 25I-NBOMe (25I) intoxication: a new potent 5-HT2A agonist designer drug. Rose SR et al. Clin Toxicol 2013;51:174-177.
The designer drug 25I-NBOMe is an extremely potent serotonin agonist. Since it is so new, there have been few case reports of toxicity reported in the medical literature. However, there have been several fatalities associated with use of …
Caster beans and ricin: At the ToxTalk podcast, Matt Zuckerman, Jen Carey, and Ed Boyer from the University of Massachusetts toxicology program have a level-headed discussion as to whether or not one should panic if an envelope filled with ricin arrives in the mail. I was especially interested to hear about their recent case of a suicidal man who …
Hemodialysis for the Treatment of Pulmonary Hemorrhage from Dabigatran Overdose. Chen BC et al. Am J Kidney Dis 2013 Apr 15 [Epub ahead of print]
Dabigatran (Pradaxa) is a competitive direct thrombin inhibitor approved in the United States for stroke prophylaxis in patients with nonvalvular atrial fibrillation. Although dabigatran has certain advantages over coumadin related to issues of dosing …
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