Complications associated with lipid emulsion therapy

March 28, 2014, 6:32 pm

intralipid_10672_5_(big)_★★★☆☆

Complications Following Antidotal Use of Intravenous Lipid Emulsion Therapy. Levine M et al. J Med Toxicol 2014 Mar;10:10-14.

Abstract

Known complications of intralipid administration include pancreatitis, acute respiratory distress syndrome (ARDS), and interference with laboratory tests. While these complications can be seen when intralipid is administered for parenteral nutrition, there is interest concerning to what extent they occur when lipid …

Read More »

Dutch marijuana trade, German meth, and more! Tox on the Web

March 26, 2014, 5:34 pm

The politics and economics of marijuana in the Netherlands: The above piece from PBS NewsHour makes the point that the illogical patchwork system controlling the market for recreational cannabis in the Netherlands is nothing like the comprehensive regulation being instigated in Colorado and Washington state. HT @erowid)

Must-read: Meth in Germany: A recent issue of Der Spiegel has an extensive …

Read More »

ED discharge prescriptions for opioid analgesics increased 49% from 2005 to 2010

March 25, 2014, 5:40 pm

450px-Hydrocodone_liquid★★★☆☆

Rising Opioid Prescribing in Adult U.S. Emergency Department Visits: 2001-2010. Mazer-Amirshahi et al. Acad Emerg Med 2014 Mar;21:236-243.

Abstract

The Centers for Disease Control and Prevention has called prescription drug overdose “the fastest growing drug problem in the United States” and an “epidemic.” Most physicians are astounded when first informed about the extent of this problem.

Test your knowledge: How …

Read More »

TPR Podcast Episode #3: Kaboom! – Exploding Toxicology

March 23, 2014, 7:47 pm

Most poisons get absorbed systemically and cause havoc in various biochemical and physiological operations. Some are caustics or irritants that can damage skin or mucosa. Very few explode, In episode 3 of the TPR podcast, we cover those that can go kaboom, along with the dreaded jalaproctitis. And, of course, we have a puzzler — the first correct answer will win a $10 Amazon gift certificate.

To view the show notes, click “Read More” below.

Play

Read More »

Cases of ADHD are skyrocketing: epidemic or conspiracy?

March 19, 2014, 2:50 am

Data suggest that cases of ADHD are skyrocketing. One in nine children receive the diagnosis by age 18, and 70% of these are prescribed stimulants or other medications. Dr. William Graf, professor of Pediatrics and Neurology at Yale, told the New York Times “These are astounding numbers. I’m floored.”

But things are about to get worse. Under new criteria published …

Read More »

Was Beethoven’s deafness caused by lead toxicity?

March 16, 2014, 10:47 pm

250px-Beethoven★★★☆☆

Lead and the Deafness of Ludwig Van Beethoven. Stevens MH et al. Laryngoscope 2013 Nov;123:2854-2858.

Abstract

Beethoven was 27 when he first experienced tinnitus and high-frequency hearing impairment. These symptoms progressed slowly until the famous incident in 1824 when the composer, attending the first performance of his Ninth Symphony, he was not able to hear the thunderous applause that …

Read More »

Imagine

March 15, 2014, 7:37 pm

With the SMACC Gold conference starting in just 3 days, the excitement is building and there is music in the air in Queensland.  All power to FOAMed!

The above bit of FOAMaoke is from Simon Carley and the St. Emlyn’s blog.…

Read More »

The science of alpha-PVP (“gravel”), a second-generation bath salt

March 14, 2014, 7:24 pm

★★★½☆

Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV). Marusich JA at al. Neuropharmacology 2014 Mar2 [Epub ahead of print]

Abstract

Earlier this month TPR noted that a relatively new second-generation bath salt call “gravel” was reported to have surfaced in various parts of the United States, including Tennessee. As background, while first-generation bath salts …

Read More »

Sriracha, Zohydro, and more: tox on the web

March 5, 2014, 3:57 pm

 

The science of Sriracha: The American Chemical Society has a must-see video on Sriracha hot sauce — it goes well with everything — including disquisitions about the origin of the Scoville scale and the physiology of capsaicinoids. (HT @ToxTalk)

Screen Shot 2014-03-05 at 1.38.40 PM

Early ads for sedatives: The Milwaukee Journal-Sentinel — which is doing some of the best reporting in the country on …

Read More »